Stem Cell Biology/Epigenetics

Postdoctoral Research/Visiting Fellowships are immediately available in Raja Jothi's laboratory at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) to study mechanisms of gene regulation in embryonic stem cells. Dr. Jothi's group is interested in understanding how transcription regulators and chromatin modifications regulate gene expression programs during cellular development and differentiation.

Recently, the group has discovered several novel regulators of embryonic stem (ES) cell maintenance using a combination of Bioinformatics and RNAi-screen approaches. Successful candidate will employ traditional functional assays in combination with array- and sequence-based high-throughput approaches (ChIP-Seq, RNA-Seq, etc) to characterize the roles of these novel regulators in ES cell self-renewal and differentiation, development, and reprogramming somatic cells into induced pluripotent stem cells (iPS). In addition, he/she will also map and characterize regulatory elements and epigenomes in human and mouse stem cells.

Access to core facilities (Next Generation Sequencing, Microarrays, Immunohistochemistry, Flow Cytometry, Histology, transgenic/knockout mice core, Viral Vectors, etc) offers the trainee wide latitude in the design and pursuit of their research questions.

Qualifications: Candidates must be completing or should have obtained a Ph.D. or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Genetics or a related discipline within the last three years. The candidate should have strong background in molecular biology, and/or protein biochemistry. Experience in stem cell biology, development, chromatin immunoprecipitation (ChIP) or RNAi is highly desirable. Excellent communications skills and the ability to work with an highly interactive, interdisciplinary team of researchers are essential.

Location: NIEHS main campus in the Research Triangle Park (RTP), North Carolina. The RTP is the largest research park in US located between Raleigh, Durham, and Chapel Hill, and is within ~12 miles from Duke University, University of North Carolina-Chapel Hill, and North Carolina State University.

Scientist magazine ranks NIEHS as the 16th best workplace for Postdocs, ahead of the National Cancer Institute (NCI), which is ranked at number 19, and NIH, which came in at 32

Stipend/Salary & Benefits: Successful candidates will be offered competitive stipend/salary commensurate with number of years of postdoctoral experience and accomplishments.

Disclaimer: The views and opinions expressed on this website do not state or reflect those of the U.S. Government, DHHS, NIH, or NIEHS.

This file was last updated on Dec 28, 2011. Copyright 2006-2011, Raja Jothi. All rights reserved.